KAT1 Products

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.

Bioinformatics

Entrez	107435 Mouse 296501 Rat 8520 Human
Uniprot	NM_001033085 Human NP_003633 Human O14929 Human
Product By Gene ID	8520
Alternate Names	EC 2.3.1.48 histone acetyltransferase 1 histone acetyltransferase type B catalytic subunit KAT1

Research Areas for KAT1

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Stem Cell Markers