JIP2 Products

Description

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Bioinformatics

Entrez	116554 Rat 23542 Human 60597 Mouse
Uniprot	AAH09940.2 Human AAH47527 Human AAH47527.1 Human NP_005447 Human Q13387 Human
Product By Gene ID	23542
Alternate Names	C-Jun-amino-terminal kinase-interacting protein 2 homologous to mouse JIP-1 IB-2 IB2JIP2Mitogen-activated protein kinase 8-interacting protein 2 islet-brain 2 islet-brain-2 Islet-brain-2 JIP-2 JNK MAP kinase scaffold protein 2 JNK MAP kinase scaffold protein JIP2 JNK-interacting protein 2 mitogen-activated protein kinase 8 interacting protein 2 PRKM8 interacting protein-like PRKM8IPL

Research Areas for JIP2

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Apoptosis