IRF9 Products

Description

Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state

Bioinformatics

Entrez	10379 Human
Uniprot	AAH35716 Human NM_006084 Human NP_006075.3 Human Q00978 Human
Product By Gene ID	10379
Alternate Names	IFN-alpha-responsive transcription factor subunit interferon regulatory factor 9 Interferon-stimulated gene factor 3 gamma interferon-stimulated transcription factor 3, gamma (48kD) interferon-stimulated transcription factor 3, gamma 48kDa IRF-9 ISGF3 p48 subunit ISGF3 ISGF3GISGF-3 gamma p48 Transcriptional regulator ISGF3 subunit gamma

Research Areas for IRF9

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Signal Transduction