CD49e is a type I integral membrane glycoprotein, known as alpha5 integrin, VLA-5 alpha chain. It forms noncovalent heterodimer with integrin beta1 (CD29). CD49e contains two disulfide-linked subunits of 135 kDa and 24 kDa, and is mainly expressed on thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells. CD49e/CD29 complex binds to fibronection and neural adhesion molecule L1. It mediates monocytes migration, involves in the regulation of cells survival and apoptosis, and co-stimulates T cell activation.
![Western Blot Integrin alpha 5/CD49e Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Integrin_alpha_5_AF1864_Western_Blot_7392.jpg)
![Simple Western Integrin alpha 5/CD49e Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/af1864_human-integrin-alpha-5-cd49e-affinity-purified-polyclonal-ab-simple-western-2642022155234.jpg)
![Flow Cytometry Integrin alpha 5/CD49e Antibody (238307) [Unconjugated]](http://images.novusbio.com/fullsize2/Integrin_alpha_5_MAB1864_Flow_Cytometry_22450.jpg)
![Immunocytochemistry Integrin alpha 5/CD49e Antibody (238307) [Unconjugated]](http://images.novusbio.com/fullsize2/mab1864_human-integrin-alpha-5-cd49e-mab-clone-238307-immunocytochemistry-1982021144632.jpg)
![N/A Integrin alpha 5/CD49e [Biotin]](http://images.novusbio.com/fullsize2/DATA_Integrin_alpha_5_DY186405_ELISA_2374.jpg)
