ILF3 Products

Description

ILF3 encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Bioinformatics

Entrez	3609 Human
Uniprot	AAH03086 Human NM_012218 Human NP_004507 Human NP_004507.2 Human NP_036350.2 Human Q12906 Human Q12906-2 Human
Product By Gene ID	3609
Alternate Names	Double-stranded RNA-binding protein 76 double-stranded RNA-binding protein, 76 kD DRBF DRBP76M-phase phosphoprotein 4 dsRNA binding protein NFAR-2/MPP4 interleukin enhancer binding factor 3, 90kDa interleukin enhancer-binding factor 3 MPHOSPH4interleukin enhancer binding factor 3, 90kD MPP4MMP4 NF90CBTF NFAR-1 NFAR2 NFARNF110 NF-AT-90 Nuclear factor associated with dsRNA Nuclear factor of activated T-cells 90 kDa nuclear factor of activated T-cells, 90 kD TCP110 TCP80 Translational control protein 80

Research Areas for ILF3

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Cell Cycle and Replication