IL-20 Products

Description

The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-lamda. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ralpha and IL-20Rbeta. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ralpha and IL-20Rbeta all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

Bioinformatics

Entrez	50604 Human 58181 Mouse
Uniprot	AAF36679 Human NP_061194 Human NP_061194.2 Human Q9JKV9.1 Mouse Q9NYY1 Human
Product By Gene ID	50604
Alternate Names	Cytokine Zcyto10 IL10D IL-20ZCYTO10four alpha helix cytokine interleukin 20 interleukin-20 MGC96907

Research Areas for IL-20

Find related products by research area and learn more about each of the different research areas below.

Biologically Active Proteins
Signal Transduction