hnRNP K Products

Description

The hnRNP-K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNPs-K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).

Bioinformatics

Entrez	117282 Rat 15387 Mouse 3190 Human
Uniprot	NM_002140 Human NM_031263 Human NP_112552 Human NP_112552.1 Human P61978 Human
Product By Gene ID	3190
Alternate Names	dC-stretch binding protein FLJ41122 heterogeneous nuclear ribonucleoprotein K hnRNP K transformation upregulated nuclear protein Transformation up-regulated nuclear protein TUNPHNRPKCSBP

Research Areas for hnRNP K

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
DNA Repair
Stem Cell Markers