hnRNP G Products

Description

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription, pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. hnRNP G is a glycoprotein, which was originally identified as an autoantigen from German shepherd dogs with lupus-like syndrome. The gene encoding hnRNP G is located on chromosome Xq26 and is ubiquitously expressed. It contains one RNP-consensus RNA binding domain (RBD) and is related to RBMY, which is involved in spermatogenesis, and hnRNP G-T, which is a testis specific protein. All three proteins interact with Tra2b and therefore, are involved in pre-mRNA splicing.

Bioinformatics

Entrez	19655 Mouse 27316 Human 302855 Rat
Uniprot	NP_002130 Human P38159 Human
Product By Gene ID	27316
Alternate Names	Glycoprotein p43 heterogeneous nuclear ribonucleoprotein G hnRNP G hnRNP-G HNRPG RBMXP1 RBMXRT RNA binding motif protein, X chromosome RNA binding motif protein, X-linked RNA-binding motif protein, X chromosome RNMX