hnRNP C1 + C2 Products

Description

RNA polymerase II transcripts in the nucleus are in complex with several proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are important in biological activities such as transcription, pre-mRNA processing, cytoplasmic mRNA translation, and turnover. hnRNPs can be isolated either by immunoprecipitation or by sucrose gradient fractionation of cell extracts. When this is performed, the hnRNPs are isolated (consisting of protein groups named A to U), and many of these protein groups consist of more than one isoform. The major steadystate proteins of the isolated hnRNP complex are the A1, A2, B1, B2, C1, and C2 with a range of molecular weight starting with 34 kDa up to 43 kDa. The hnRNP-C proteins have a single RNP motif RNA-binding domain (RBD) of 80 to 100 amino acid long. The hnRNP -C proteins preferentially bind to uridine-rich RNA sequences. Oligomerization of the protein through leucine rich regions in its C-terminal end is important for RNA binding.4 Although its physiological action is unknown, mutation of the hnRNPC gene causes a embryonic lethal phenotype.

Bioinformatics

Entrez	15381 Mouse 290046 Rat 3183 Human
Uniprot	AAH89438.1 Human NM_004500 Human NP_001070910 Human NP_004491 Human NP_112604 Human P07910 Human
Product By Gene ID	3183
Alternate Names	C1 C2 heterogeneous nuclear ribonucleoprotein C (C1/C2) heterogeneous nuclear ribonucleoproteins C1/C2 hnRNP C1/C2 HNRNP hnRNPC HNRPC MGC104306 MGC105117 MGC117353 MGC131677 nuclear ribonucleoprotein particle C1 protein nuclear ribonucleoprotein particle C2 protein SNRPC

Research Areas for hnRNP C1 + C2

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
DNA replication, Transcription, Translation and Splicing