HLA DRB5 Products

Description

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

Bioinformatics

Entrez	3127 Human
Uniprot	AAH09234 Human NP_002116 Human NP_002116.2 Human
Product By Gene ID	3127
Alternate Names	DR beta-5 DR2-beta-2 DR9 DR-9 Dw2 dw2 FLJ76359 HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DR-5 beta chain HLA class II histocompatibility antigen, DRB1-9 beta chain HLA-DRB human leucocyte antigen DRB5 leukocyte antigen class II major histocompatibility complex, class II, DR beta 5 MHC class II antigen DRB1*9 MHC class II antigen DRB5 MHC class II HLA beta chain MHC HLA-DR-beta cell surface glycoprotein MHC HLA-DR-beta chain

Research Areas for HLA DRB5

Find related products by research area and learn more about each of the different research areas below.

Asthma
Diabetes Research
Immunology