HLA DRB3 Products

Description

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

Bioinformatics

Entrez	3125 Human
Uniprot	AAH08987 Human AAH08987.1 Human NP_072049 Human NP_072049.2 Human P79483 Human
Product By Gene ID	3125
Alternate Names	DR7 HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DRB1-7 beta chain HLA-DR3B HLA-DR52 HLA-DRB1 human leucocyte antigen DRB3 major histocompatibility complex, class II, DR beta 3 MGC117330 MHC class II antigen DR beta 3 chain MHC class II antigen DRB3 MHC class II HLA-DR beta 3 chain

Research Areas for HLA DRB3

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology