HLA DRA Products

Description

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Bioinformatics

Entrez	3122 Human
Uniprot	AAH32350 Human NM_019111 Human NP_061984 Human NP_061984.2 Human
Product By Gene ID	3122
Alternate Names	FLJ51114 histocompatibility antigen HLA-DR alpha HLA class II histocompatibility antigen, DR alpha chain HLA-DRA1 major histocompatibility complex, class II, DR alpha MHC cell surface glycoprotein MHC class II antigen DRA MLRW

Research Areas for HLA DRA

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Adaptive Immunity
Cell Biology
Diabetes Research
Immunology

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