HLA DQA1 Products

Description

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]

Bioinformatics

Entrez	3117 Human
Uniprot	NM_002122 Human NP_002113 Human NP_002113.2 Human
Product By Gene ID	3117
Alternate Names	CD CELIAC1DQ alpha 1 chain DC-1 alpha chain DQ-A1 FLJ27088 FLJ27328 GSE HLA class II histocompatibility antigen, DQ(W3) alpha chain HLA-DCA HLA-DQA leucocyte antigen DQA1 leukocyte antigen alpha chain major histocompatibility complex, class II, DQ alpha 1 MGC149527 MHC class II antigen MHC class II DQA1 MHC class II HLA-D alpha glycoprotein MHC class II HLA-DQ-alpha-1 MHC class II surface glycoprotein MHC HLA-DQ alpha

Research Areas for HLA DQA1

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Asthma
Immunology