Species: Hu, Mu
Applications: WB
Host: Rat Monoclonal
Species: Hu, Mu
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, ELISA, Func
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Description
The 60-kilodalton protein encoded by HCK resembles the product of the proto-oncogene c-src and is therefore likely to be a peripheral membrane protein (1). Protein-tyrosine kinase Hck is primarily expressed in hematopoietic cells, particularly granulocytes. Protein-tyrosine kinases are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes and as components of growth factor receptors (2). Tyrosine kinases of the Src family are regulated via their Src homology 2 (SH2) and SH3 domains. The Nef protein of human immunodeficiency virus-1 (HIV-1) has previously been shown to bind with high affinity and specificity in vitro to the SH3 domain of Hck, a Src family member expressed primarily in myeloid cells. Results provide direct evidence that SH3 engagement is sufficient to activate a Src family kinase in vivo and suggest that Hck may be activated by Nef in HIV-infected macrophages (3).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
3055 |
| Alternate Names |
- EC 2.7.10
- EC 2.7.10.2
- hemopoietic cell kinaseJTK9
- p59-HCK/p60-HCK
- tyrosine-protein kinase HCK
|
