GTF2A2 Products

Description

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM]

Bioinformatics

Entrez	235459 Mouse 2958 Human 83828 Rat
Uniprot	AAH00287 Human AAH00287.1 Human AAH01919 Human NM_004492 Human NP_004483.1 Human P52657 Human
Product By Gene ID	2958
Alternate Names	General transcription factor IIA subunit 2 general transcription factor IIA, 2 (12kD subunit) general transcription factor IIA, 2, 12kDa HsT18745 TF2A2 TFIIA p12 subunit TFIIA TFIIA-12 TFIIA-gamma TFIIAS Transcription initiation factor IIA gamma chain transcription initiation factor IIA subunit 2