GSK-3 alpha Products

Description

Glycogen synthases kinase 3 alpha (GSK3-alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-alpha activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4).

Bioinformatics

Entrez	2931 Human 50686 Rat 606496 Mouse
Uniprot	AAH27984 Human NM_019884 Human NP_063937 Human NP_063937.2 Human P49840 Human
Product By Gene ID	2931
Alternate Names	DKFZp686D0638 EC 2.7.11 EC 2.7.11.26 glycogen synthase kinase 3 alpha glycogen synthase kinase-3 alpha GSK-3 alpha

Research Areas for GSK-3 alpha

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Hypoxia
Phospho-Specific
Protein Kinase
Signal Transduction
Stem Cell Markers