Granzyme H Products

Description

The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and granzyme B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H, also designated cytotoxic T-lymphocyte proteinase, cathepsin G-like 2 (CTSGL2) or cytotoxic serine protease C (CSP-C), contains one peptidase S1 domain. Granzyme H localizes to cytoplasmic granules of cytolytic T-lymphocytes and is important for target cell lysis in cell-mediated immune responses.

Bioinformatics

Entrez	2999 Human
Uniprot	AAH27974 Human NP_219491 Human NP_219491.1 Human P10144 Human P20718 Human
Product By Gene ID	2999
Alternate Names	Cathepsin G-like 2 CCP-Xcytotoxic T-lymphocyte-associated serine esterase 1 CGL2 CGL-2 CSP-Ccytotoxin serine protease-C CTLA1 CTSGL2granzyme H Cytotoxic serine protease C Cytotoxic T-lymphocyte proteinase EC 3.4.21 EC 3.4.21.- EC 3.4.21.79 granzyme H (cathepsin G-like 2, protein h-CCPX)

Research Areas for Granzyme H

Find related products by research area and learn more about each of the different research areas below.

Apoptosis