Species: Mu, Am
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
2796 |
| Alternate Names |
- GNRH
- GnRH-associated peptide 1
- gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
- gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
- GRH
- LHRH
- LNRH
- luliberin I
- Progonadoliberin I
- progonadoliberin-1
- prolactin release-inhibiting factor
|
Research Areas for GnRH
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and ReplicationGPCR
