gamma-Synuclein Products

Description

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. May be a centrosome-associated protein. Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family.

Bioinformatics

Entrez	6623 Human
Uniprot	AAC27738 Human AAH14098 Human AAH14098.1 Human NP_003078 Human NP_003078.2 Human O76070 Human
Product By Gene ID	6623
Alternate Names	BCSG1PERSYN Breast cancer-specific gene 1 protein gamma-synuclein Persyn persyn SRPRSN Synoretin synoretin synuclein, gamma (breast cancer-specific protein 1)

Research Areas for gamma-Synuclein

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Cellular Markers
Mitotic Regulators
Neuroscience