GABA-AR alpha 3 Products

Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003).

Bioinformatics

Entrez	14396 Mouse 24947 Rat 2556 Human
Uniprot	AAH28629 Human NM_000808 Human P20236 Rat P34903 Human
Product By Gene ID	2556
Alternate Names	GABA(A) receptor subunit alpha-3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 gamma-aminobutyric acid receptor subunit alpha-3 gamma-animobutyric acid (GABA) A receptor, alpha 3 MGC33793