FUS Products

Description

FUS, fused in sarcoma, encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Bioinformatics

Entrez	233908 Mouse 2521 Human
Uniprot	NM_004960 Human P35637 Human P56959 Mouse
Product By Gene ID	2521
Alternate Names	75 kDa DNA-pairing protein ALS6 amyotrophic lateral sclerosis 6 FUS1 fused in sarcoma fusion (involved in t(12;16) in malignant liposarcoma) fusion gene in myxoid liposarcoma fusion, derived from t(12;16) malignant liposarcoma fus-like protein heterogeneous nuclear ribonucleoprotein P2 HNRNPP2 Oncogene FUS Oncogene TLS POMP75 POMp75 RNA-binding protein FUS TLShnRNP-P2 Translocated in liposarcoma protein

Research Areas for FUS

Find related products by research area and learn more about each of the different research areas below.

Cancer
Neuroscience

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Transportin 1 and heterogeneous nuclear ribonucleoprotein D (hnRNPD) Transportin 1, also known as Karyopherin- beta 2 or Importin- beta 2, is part of the beta -karyopherins family, which consists of importins and exportins responsible for the active transport of proteins between the nucleus and cytoplasm.  Transportin 1 is co...    Read more.

Amyotrophic Lateral Sclerosis Infographic Amyotrophic lateral sclerosis is a neurological disease which impacts motor neurons that are involved in muscle movement throughout the body. The progressive degeneration of neurons causes weakened muscles and can lead to paralysis. There is no cure f...    Read more.

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