FOXL1 Products

Description

FOXL1 is a 337 amino acid protein encoded by the mouse gene Foxl1. FOXL1 belongs to the fork head family and contains one fork head DNA-binding domain. The HNF3/fork head family includes a large number of transcription factors that share a structurally related DNA binding domain. Fork head factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1- deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyer's patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the adenomatous polyposis coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.

Bioinformatics

Entrez	2300 Human
Uniprot	AAI00028.1 Human NP_005241 Human NP_005241.1 Human Q12952 Human
Product By Gene ID	2300
Alternate Names	FKH6forkhead box protein L1 FKHL11forkhead-like 11 forkhead box L1 Forkhead-related protein FKHL11 Forkhead-related transcription factor 7 FREAC7FREAC-7