Fibrillarin Products

Description

Nop1p / Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646). The Nop1p protein is essential for yeast viability and is localized in the nucleoli. The human homologue of Nop1p is fibrillarin (accession P22087) a component of the nucleolar small nuclear ribonucleoprotein (snRNP) particle. The human fibrillarin gene is located on chromosome 19 (19q13.1). Fibrillarin proteins have been cloned and sequenced from several other species (Mouse, accession P35550, Xenopus accession P22232, C. elegans accession Q22053, and S. pombe accession P35551). The N terminal 80 amino acids contain multiple copies based on the peptide RGG, and the remaining 240 amino acids consist of the fibrillarin domain. A fibrillarin homologue has also been identified in the genome of the archean Methanococcus (accession NC_000909). This protein lacks the RGG rich N-terminal extension but is clearly homologous to the other sequences throughout all of the fibrillarin domain. The structure of this molecule has been determined and shown to consist of 2 extended beta-sheets flanked by 4 alpha-helixes. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a 34kDa protein which was subsequently found to be fibrillarin. Fibrillarin is an excellent marker for the nucleolus.

Bioinformatics

Entrez	14113 Mouse 2091 Human 292747 Rat
Uniprot	AAH19260 Human AAH19260.1 Human NM_001436 Human NP_001427 Human P22087 Human
Product By Gene ID	2091
Alternate Names	EC 2.1.1,34-kD nucleolar scleroderma antigen EC 2.1.1.- EC 2.1.1.37 FIB FIB1,34 kDa nucleolar scleroderma antigen fibrillarin FLRNrRNA 2'-O-methyltransferase fibrillarin RNA, U3 small nucleolar interacting protein 1 RNU3IP1

Research Areas for Fibrillarin

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Core ESC-Like Genes
Neuroscience
Nuclear Envelope Markers
Stem Cell Markers