FANCL Products

Description

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq]

Bioinformatics

Entrez	305600 Rat 55120 Human 67030 Mouse
Uniprot	AAH54517 Human NM_018062 Human NP_001108108.1 Human NP_060532.2 Human
Product By Gene ID	55120
Alternate Names	E3 ubiquitin-protein ligase FANCL EC 6.3.2.- FAAP43PHF9FLJ10335 Fanconi anemia group L protein Fanconi anemia, complementation group L Fanconi anemia-associated polypeptide of 43 kDa PHD finger protein 9 POG Pog

Research Areas for FANCL

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Genes Sensitive to DNA Damaging Agents

Related FANCL Blog Posts

Check out the latest blog posts on FANCL.

Fanconi Antibodies and Cancer Research We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)...    Read more.

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