Species: Hu
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Monoclonal
Species: Hu
Applications: IP, WB (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
2187 |
| Alternate Names |
- EC 2.8.1
- EC 3.6.3.14
- FA2
- FAAP90
- FAAP95FAB
- FACB
- Fanconi anemia group B protein
- Fanconi anemia, complementation group B
- Fanconi anemia-associated polypeptide of 95 kDa
- FLJ34064
- Protein FACB
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Related FANCB Blog Posts
Check out the latest blog posts on FANCB.
Fanconi Antibodies and Cancer Research
We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)... Read more.
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Read more FANCB related blogs.
