FADD Products

Description

Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.

Bioinformatics

Entrez	14082 Mouse 266610 Rat 8772 Human
Uniprot	AAA97876 Mouse AAH00334 Human NM_003824 Human NP_003815 Human NP_003815.1 Human Q13158 Human Q61160 Mouse
Product By Gene ID	8772
Alternate Names	Fas (TNFRSF6)-associated via death domain FAS-associated death domain protein FAS-associating death domain-containing protein GIG3 Growth-inhibiting gene 3 protein Mediator of receptor induced toxicity mediator of receptor-induced toxicity MGC8528 MORT1Fas-associating protein with death domain protein FADD

Research Areas for FADD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Diabetes Research
Phospho-Specific
Tumor Suppressors

Related FADD Blog Posts

Check out the latest blog posts on FADD.

Apoptosis and Necroptosis Part I: Important factors to identify both types of programmed cell death Different types of cell death have classically been identified by discrete morphological changes. The hallmarks of apoptosis include cell shrinkage, nuclear fragmentation and membrane blebbing whereas necroptosis is characterized by cell swelling ...    Read more.

Caspase 9: The Suicidal Cell Whisperer Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include ...    Read more.

Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were ...    Read more.

FADD - important initiator of death receptor-mediated apoptosis FAS-associated death domain protein (FADD) is a 23 kDa adaptor protein involved in initiating apoptosis. FADD is best known for its involvement in extrinsic/death receptor-mediated apoptosis, but it is also involved in initiating necroptosis with ...    Read more.

Read more FADD related blogs.