FA2H Products

Description

Sphingolipids are a large class of lipids found in all eukaryotic cells and are involved in numerous cellular processes. The structural diversity of sphingolipids stems from more than 300 distinct head groups, as well as from modifications of the hydrophobic ceramide moiety. FA2H catalyzes a common modification of the ceramide moiety: hydroxylation at the 2 position of the N-acyl chain. Sphingolipids containing 2-hydroxy fatty acid are common in nervous and epidermal tissue. Glycosphingolipids containing a high proportion of 2-hydroxy fatty acid are critical components of myelin, and several very long chain ceramides with 2-hydroxy fatty acids are important for the permeability barrier function of epidermis (Alderson et al., 2004 [PubMed 15337768]).[supplied by OMIM]

Bioinformatics

Entrez	79152 Human
Uniprot	AAH17049.2 Human NM_024306 Human
Product By Gene ID	79152
Alternate Names	FAAHFAXDC1 FAH1 fatty acid 2-hydroxylase Fatty acid alpha-hydroxylase fatty acid hydroxylase domain containing 1 FLJ25287 SCS7 spastic paraplegia 35 (autosomal recessive) SPG35

Research Areas for FA2H

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism