Species: Mu
Applications: WB
Host: Goat Polyclonal
Species: Mu
Applications: WB
Host: Rat Monoclonal
Species: Hu
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Species: Mu
Applications: Binding Activity
Species: Hu
Applications: Bioactivity
Description
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8(Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5(Hek9) and EphB6 (Mep). EphAs are a family of receptor tyrosine kinases that are involved in axonal guidance during development. These receptors and their ligands, the ephrins, act via repulsive mechanisms to guide growing axons towards their appropriate targets and allow for the correct developmental connections to be made. Ligand binding to an Eph receptor results in tyrosine phosphorylation of the kinase domain, and repulsion of axonal growth cones and migrating cells. During neurulation, ephrin-A5 is coexpressed with its cognate receptor EphA7 in cells at the edges of the dorsal neural folds. Three different EphA7 splice variants, a full-length form and two truncated versions lacking kinase domains, are expressed in the neural folds.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
2045 |
| Alternate Names |
- EC 2.7.10
- EC 2.7.10.1
- EHK3
- EHK-3
- EK11
- EPH homology kinase 3
- Eph homology kinase-3
- EPH receptor A7
- EphA7
- EPH-like kinase 11
- ephrin type-A receptor 7
- HEK11
- hEK11
- Hek11
- receptor protein-tyrosine kinase HEK11
- tyrosine-protein kinase receptor EHK-3
|
