EDA2R/TNFRSF27/XEDAR Products

Description

EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support.

Bioinformatics

Entrez	60401 Human
Uniprot	AAQ89953 Human NP_068555 Human NP_068555.1 Human Q9HAV5 Human
Product By Gene ID	60401
Alternate Names	ectodysplasin A2 receptor EDA-A2 receptor EDA-A2R EDAA2Rtumor necrosis factor receptor superfamily member XEDAR EDAR2 XEDARTNFRSF27tumor necrosis factor receptor superfamily member 27 X-linked ectodysplasin-A2 receptor