dUTPase Products

Description

dUTPase encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Bioinformatics

Entrez	1854 Human
Uniprot	AAH33645 Human AAH33645.1 Human NM_001948 Human NP_001020419 Human NP_001020419.1 Human P33316 Human
Product By Gene ID	1854
Alternate Names	deoxyuridine triphosphatase dUTP pyrophosphatasedUTP nucleotidohydrolase dUTPasedeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial EC 3.6.1.23 FLJ20622

Research Areas for dUTPase

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Lipid and Metabolism