DUSP8 Products

Description

DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Bioinformatics

Entrez	18218 Mouse 1850 Human
Uniprot	NP_004411 Human Q13202 Human
Product By Gene ID	1850
Alternate Names	C11orf81 chromosome 11 open reading frame 81 dual specificity phosphatase 8 Dual specificity protein phosphatase hVH-5 EC 3.1.3.16 EC 3.1.3.48 FLJ42476 FLJ42958 HVH8 serine/threonine specific protein phosphatase vaccinia virus homolog VH5

Research Areas for DUSP8

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Signal Transduction