Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures.Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neuriteoutgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interactionwith LRP6, thereby acting as an antagonist of Wnt signaling pathway