Dnmt3L Products

Description

DNMT 3L is a nuclear protein which has similarity to DNA methyltransferases, involved in de novo methylation of CpG islands. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.

Bioinformatics

Entrez	29947 Human
Uniprot	AAH02560.1 Human BAA95556 Human NM_013369 Human NM_175867 Human NP_037501 Human Q9UJW3 Human
Product By Gene ID	29947
Alternate Names	DNA (cytosine-5-)-methyltransferase 3-like DNA (cytosine-5)-methyltransferase 3-like human cytosine-5-methyltransferase 3-like protein, 10cytosine-5-methyltransferase 3-like protein MGC1090

Research Areas for Dnmt3L

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Chromatin Research

Related Dnmt3L Blog Posts

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The role of DNMT3A in development Epigenetics is the study of heritable change in gene activity despite alteration of the hosts DNA sequence.  Change in gene activity done independently of the DNA sequence is achieved by way of histone and DNA methylation.  Gene silencing in DNA ...    Read more.

The role of DNMT3B in the co-incidence of methyltransferase and tumor suppressor expression in malignancies Epigenetics is the process of heritable change in gene activity despite alteration of the hosts DNA sequence, essentially causing a change in a phenotype without a change in the genotype of a host. To change the gene sequence without interfering w...    Read more.

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