DHPS Products

Description

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.

Bioinformatics

Entrez	1725 Human
Uniprot	AAH14016 Human NM_001930 Human NP_001921 Human NP_001921.1 Human P49366 Human
Product By Gene ID	1725
Alternate Names	deoxyhypusine synthase DHS DS EC 2.5.1 EC 2.5.1.46 hypusine MIG13 migration-inducing gene 13

Research Areas for DHPS

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication