Creatine kinase MT 1A Products

Description

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to thecytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes,sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two differentoligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes.Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; thismay be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrialcreatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes locatednear each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.(provided by RefSeq)

Bioinformatics

Entrez	548596 Human
Uniprot	P12532 Human
Product By Gene ID	548596
Alternate Names	Acidic-Type Mitochondrial Creatine Kinase CKMT CKMT1 CKMT1A Creatine Kinase U-Type, Mitochondrial Creatine Kinase, Mitochondrial 1 (Ubiquitous) Creatine Kinase, Mitochondrial 1A EC 2.7.3.2 Mia-CK Ubiquitous Mitochondrial Creatine Kinase U-MtCK

Research Areas for Creatine kinase MT 1A

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Protein Kinase