Chk1 Products

Description

Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).

Bioinformatics

Entrez	1111 Human 12649 Mouse 140583 Rat
Uniprot	AAH04202 Human ABM87141.1 Human NM_001274 Human NP_001107593 Human NP_001107594 Human NP_001265 Human O14757 Human
Product By Gene ID	1111
Alternate Names	Checkpoint, S. pombe, homolog of, 1 CHK1 (checkpoint, S.pombe) homolog CHK1 checkpoint homolog (S. pombe) CHK1serine/threonine-protein kinase Chk1 EC 2.7.11 EC 2.7.11.1

Research Areas for Chk1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific
Stem Cell Markers
Tumor Suppressors