CCM2 Products

Description

p16 INK4a is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

Bioinformatics

Entrez	216527 Mouse 83605 Human
Uniprot	NM_031443 Human NP_001025006.1 Human NP_113631 Human NP_113631.1 Human Q9BSQ5 Human
Product By Gene ID	83605
Alternate Names	C7orf22OSM cerebral cavernous malformation 2 Cerebral cavernous malformations 2 protein chromosome 7 open reading frame 22 malcavernin MGC4067 MGC4607 MGC74868