CBFA2T3 Products

Description

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus. [provided by RefSeq]

Bioinformatics

Entrez	863 Human
Uniprot	AAH62624.1 Human NP_005178 Human O75081 Human
Product By Gene ID	863
Alternate Names	core-binding factor, runt domain, alpha subunit 2; translocated to, 3 hMTG16 MTG16ETO2 MTG8-related protein 2 MTGR2MTG8-related gene 2 Myeloid translocation gene on chromosome 16 protein protein CBFA2T3 Zinc finger MYND domain-containing protein 4 ZMYND4myeloid translocation gene 8 and 16b