CACNA1S Products

Description

Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.

Bioinformatics

Entrez	682930 Rat 779 Human
Uniprot	NP_000060 Human
Product By Gene ID	779
Alternate Names	CACH1 CACN1 CACNL1A3MHS5 calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle calcium channel, voltage-dependent, L type, alpha 1S subunit Cav1.1 CCHL1A3 dihydropyridine receptor dihydropyridine-sensitive L-type calcium channel alpha-1 subunit HOKPP HOKPP1 hypokalemic periodic paralysis) hypoPP TTPP1 voltage-dependent L-type calcium channel subunit alpha-1S Voltage-gated calcium channel subunit alpha Cav1.1

Research Areas for CACNA1S

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Signal Transduction