c-Rel Products

Description

The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM]

Bioinformatics

Entrez	19696 Mouse 5966 Human
Uniprot	NP_002899 Human NP_002899.1 Human Q04864 Human
Product By Gene ID	5966
Alternate Names	C-Rel proto-oncogene protein C-Rel c-Rel I-Rel oncogene REL, avian reticuloendotheliosis proto-oncogene c-Rel v-rel avian reticuloendotheliosis viral oncogene homolog v-rel reticuloendotheliosis viral oncogene homolog (avian)

Research Areas for c-Rel

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors

Related c-Rel Blog Posts

Check out the latest blog posts on c-Rel.

NFkB and p62 Both Activate and Regulate Inflammation Nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) is a protein complex that regulates DNA transcription and is a critical regulator of cell survival. NFkB has long been known as a primer of inflammation, however researchers are ...    Read more.

Nuclear Factor kappa B Signaling in the Immune System Nuclear Factor kappa B (NFkB) binds to the kappa-beta site of the immunoglobulin kappa light chain gene enhancer. Thus NFkB has become one of the widely studied transcription factors in innate and adaptive immune responses. The NFkB family is composed...    Read more.

RelA/NF-kB - A proinflammatory signaling pathway with roles in immunity and cancer The inflammatory response consists of a complex network of signaling pathways that regulate a diverse set of cytokines, growth factors, adhesion molecules, and transcription factors (1). Of the proinflammatory signaling pathways the NF-kB family is...    Read more.

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