C-Reactive Protein/CRP Products

Description

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.

Bioinformatics

Entrez	12944 Mouse 1401 Human
Uniprot	CAA39671.1 Human ENSP00000357093 Human NP_000558 Human P02741 Human
Product By Gene ID	1401
Alternate Names	C-reactive protein C-reactive protein, pentraxin-related MGC88244 pentraxin 1 PTX1MGC149895

Research Areas for C-Reactive Protein/CRP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cytokine Research
Immunology
Innate Immunity