BMX Products

Description

The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Emt (also known as Itk or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The 72 kDa Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The 80 kDa Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

Bioinformatics

Entrez	660 Human
Uniprot	AAH16652 Human NM_001721 Human NP_975010 Human P51813 Human
Product By Gene ID	660
Alternate Names	BMX non-receptor tyrosine kinase Bone marrow tyrosine kinase gene in chromosome X protein EC 2.7.10 EC 2.7.10.2 Epithelial and endothelial tyrosine kinase Etk/Bmx cytosolic tyrosine kinase ETKcytoplasmic tyrosine-protein kinase BMX NTK38 tyrosine kinase NTK38 PSCTK2 PSCTK3

Research Areas for BMX

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase