ASPP1 Products

Description

The ASPP family members ASPP1, ASPP2, act as potent activators of p53. A third member of the family, iASPP, has an inhibitory effect on apoptosis. The three members of ASPP family all bind p53 via their C-terminus, which contains a proline-rich region, four ankyrin repeats and an SH3 domain. Expression of ASPP1 and ASPP2 is frequently downregulated in human breast tumors expressing wild-type p53. ASPP1 may also play a role in vascular development.

Bioinformatics

Entrez	23368 Human
Uniprot	NP_056131 Human Q96KQ4 Human
Product By Gene ID	23368
Alternate Names	apoptosis-stimulating protein of p53, 1 ASPP1Protein phosphatase 1 regulatory subunit 13B KIAA0771apoptosis-stimulating of p53 protein 1 p53BP2-like p85 protein phosphatase 1, regulatory (inhibitor) subunit 13B