APBB2 Products

Description

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down's syndrome and a variety of neurological disorders, including Alzheimer's disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid ®/A4 protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane- bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer disease patients.

Bioinformatics

Entrez	305338 Rat 323 Human
Uniprot	AAH27946 Human AAH27946 Human ABM85666.1 Human ABM85666.1 Human NP_775098 Human Q92870 Human Q92870 Human Q92870 Human
Product By Gene ID	323
Alternate Names	amyloid beta (A4) precursor protein-binding, family B, member 2 amyloid beta A4 precursor protein-binding family B member 2 DKFZp434E033 FE65L1FE65LMGC35575 Fe65-like 1 Protein Fe65-like 1

Research Areas for APBB2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific