ALK/CD246 Products

Description

ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23 (1). In the predicted hybrid protein, the amino terminus of NPM is linked to the catalytic domain of ALK. Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the neonatal brain (2). Also expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas (3).

Bioinformatics

Entrez	11682 Mouse 238 Human
Uniprot	NP_004295 Human Q9UM73 Human
Product By Gene ID	238
Alternate Names	ALK tyrosine kinase receptor anaplastic lymphoma kinase (Ki-1) Anaplastic lymphoma kinase anaplastic lymphoma receptor tyrosine kinase CD246 antigen CD246 EC 2.7.10.1 NBLST3

Research Areas for ALK/CD246

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Phospho-Specific
Protein Kinase
Signal Transduction