AKAP13 Products

Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.

Bioinformatics

Entrez	11214 Human
Uniprot	NM_006738 Human NM_007200 Human NM_144767 Human NP_006729 Human Q12802 Human
Product By Gene ID	11214
Alternate Names	A kinase (PRKA) anchor protein 13 AKAP-LbcAKAP-13 A-kinase anchor protein 13 A-kinase anchoring protein ARHGEF13 Breast cancer nuclear receptor-binding auxiliary protein BRXNon-oncogenic Rho GTPase-specific GTP exchange factor c-lbc FLJ11952 FLJ43341 Guanine nucleotide exchange factor Lbc HA-3 Ht31 HT31 Human thyroid-anchoring protein 31 LBCLBC oncogene Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13 p47 PROTO-LB PROTO-LBC

Research Areas for AKAP13

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Breast Cancer