Adenine Nucleotide Translocase 1 Products

Description

Adenine Nucleotide Translocase 1 (ANT1) catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. It is is a key component of the mitochondrial permeability transition pore (PT pore) complex and is also one of the most abundant proteins in the mitochondrion making up approximately 10% of all mitochondrial proteins. Originally described as an ADP/ATP exchange factor, ANT1 has also been shown to be required for bax mediated apoptosis. This is effected by binding of bax to residues 105-156 of ANT1, presumably resulting in maintaining the PT pore in an open conformation. Interaction with bax is not required for ANT1 pro-apoptotic activity as overexpression of the ANT1 protein also leads to the induction of apoptosis.

Bioinformatics

Entrez	291 Human
Uniprot	AAH08664 Human NM_001151 Human NP_001142.2 Human P12235 Human
Product By Gene ID	291
Alternate Names	AAC1 Adenine nucleotide translocator 1 ADP ADP ADP ADP/ATP translocase 1 ANT 1 ANT1adenine nucleotide translocator 1 (skeletal muscle) ATP carrier protein 1 ATP carrier protein, heart/skeletal muscle isoform T1 ATP carrier protein, heart/skeletal muscle heart/skeletal muscle ATP/ADP translocator PEO2 PEO3 solute carrier family 25 (mitochondrial carrier; adenine nucleotidetranslocator), member 4 Solute carrier family 25 member 4 T1ANT

Related Adenine Nucleotide Translocase 1 Blog Posts

Check out the latest blog posts on Adenine Nucleotide Translocase 1.

New Players in the Mitophagy Game By Christina Towers, PhD Mitochondrial turn over via the lysosome, otherwise known as mitophagy, involves engulfment of mitochondria into double membrane autophagosomes and subsequent fusion with lysosomes. Much is al...    Read more.

Read more Adenine Nucleotide Translocase 1 related blogs.