ADAMTS2 Products

Description

ADAMTS2 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in two transcript variants. The short transcript encodes a protein which has no significant procollagen N-peptidase activity.

Bioinformatics

Entrez	9509 Human
Uniprot	NP_055059 Human O95450 Human
Product By Gene ID	9509
Alternate Names	A disintegrin and metalloproteinase with thrombospondin motifs 2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 ADAM-TS 2 ADAMTS-2 ADAM-TS2EC 3.4.24.14 ADAMTS-3 EC 3.4.24 NPIDKFZp686F12218 PC I-NP PCI-NP PCINPhPCPNI PCPNI pNPI PNPI Procollagen I N-proteinase Procollagen I/II amino propeptide-processing enzyme Procollagen N-endopeptidase

Research Areas for ADAMTS2

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Extracellular Matrix