ACMSD Products

Description

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM]

Bioinformatics

Entrez	130013 Human
Uniprot	AAH16018.1 Human NP_612199 Human Q8TDX5 Human
Product By Gene ID	130013
Alternate Names	aminocarboxymuconate semialdehyde decarboxylase EC 4.1.1.45,2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Picolinate carboxylase