ABCC5 Products

Description

ABCC5 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq]

Bioinformatics

Entrez	10057 Human 116721 Rat 27416 Mouse
Uniprot	NP_001018881 Human NP_001018881.1 Human NP_005679 Human NP_005679.2 Human Q86W30 Human
Product By Gene ID	10057
Alternate Names	ATP-binding cassette sub-family C member 5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 canalicular multispecific organic anion transporter C EST277145 MOAT-CABC33 MRP5MOATC multidrug resistance-associated protein 5 Multi-specific organic anion transporter C pABC11 SMRPDKFZp686C1782

Research Areas for ABCC5

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Amino Acids, Drugs and other small molecules
Lipid and Metabolism